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The balance of baseline characteristics between the two groups was assessed using standardized difference (STD), where an absolute STD value 50%) between groups was compared using the Fine and Gray subdistribution hazard model which considered all-cause death during follow-up as a competing risk

They can directly secrete drug-metabolizing enzymes, adjust host metabolizing enzymes expression and action, and the bacterial metabolites can compete with drugs for receptors and transporters [27]

This prolonged half-life comes from two key structural modifications

For mild cases, a physician may consider its use with caution while closely monitoring symptoms